How to Release DMT

How to Release DMT

How to release dmt? DMT is the most powerful hallucinogen known and it is a major psychoactive component in ayahuasca, a beverage commonly used by indigenous Amazonian shamans. It is also used to simulate a near-death experience and can be a powerful inducer of visual, somatic and emotional effects (Strassman et al., 1994).

How do DMTs work?

It is synthesised by aromatic L-amino acid decarboxylase and indolethylamine-N, N-methyltransferase from tryptophan (2) via the N, N-dimethylation of TA. These enzymes are also responsible for the synthesis of other hallucinogenic and non-hallucinogenic compounds including 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) and bufotenine as well as psilocybin mushrooms.

In the brain DMT can be synthesized in a number of ways but it is thought that endogenous DMT is primarily formed from TA and INMT in the pineal gland. A recent study from the University of Michigan found that DMT levels in the rat brain spiked dramatically during cardiac arrest and this may be responsible for the psychedelic experiences reported by people during a NDE or while dreaming near death.

In order to determine if DMT is naturally present in the human body and brain, additional research in this area is necessary. This will involve studies that eliminate possible dietary sources and other factors that might influence DMT levels such as circadian or diurnal variations, sleep stages and gender-age-related differences. Additionally, determining the co-localization of INMT with AADC will be important for further understanding the biosynthesis of DMT in the brain. Finally, a further investigation into the binding of endogenous DMT to sigma-1 receptors is required for further clarification of its role in the human mind and brain.